Effient

Effient is a brand name of prasugrel, approved by the FDA in the following formulation(s):

EFFIENT (prasugrel hydrochloride - tablet; oral)

• 
  Manufacturer: ELI LILLY AND CO
  
  Approval date: July 10, 2009
  
  Strength(s): EQ 10MG BASE ^[RLD], EQ 5MG BASE
  

Has a generic version of Effient been approved?

No. There is currently no therapeutically equivalent version of Effient available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Effient. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

• 
  Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation
  Patent 5,288,726
  Issued: February 22, 1994
  Inventor(s): Koike; Hiroyuki & Asai; Fumitoshi & Sugidachi; Atsuhiro & Kimura; Tomio & Inoue; Teruhiko & Nishino; Shigeyoshi & Tsuzaki; Yasunori
  Assignee(s): Ube Industries Limited
  Sankyo Company, Limited
  Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.
  
  Patent expiration dates:
  
  
  • April 14, 2017
    
    ✓ 
    Patent use: TREATMENT OR PROPHYLAXIS OF THROMBOSIS OR EMBOLISMS
    ✓ 
    Drug substance
    ✓ 
    Drug product
  
  



• 
  Acid addition salts of hydropyridine derivatives
  Patent 6,693,115
  Issued: February 17, 2004
  Inventor(s): Fumitoshi; Asai & Taketoshi; Ogawa & Hideo; Naganuma & Naotoshi; Yamamura & Teruhiko; Inoue & Kazuyoshi; Nakamura
  Assignee(s): Sankyo Company, Limited
  Ube Industries Ltd.
  Acid addition salts of 2-acetoxy-5-(&agr;-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present invention exhibit excellent oral absorption, metabolization into the active compound, and platelet aggregation-inhibiting effects, low toxicity, and excellent storage and handling stabilities, and are useful as medicaments, preferably preventive or therapeutic agents (particularly therapeutic agents) for diseases caused by a thrombus or an embolus, still more preferably preventive or therapeutic agents (particularly therapeutic agents) for thrombosis or embolism.
  
  Patent expiration dates:
  
  
  • July 3, 2021
    
    ✓ 
    Patent use: TREATMENT OR PROPHYLAXIS OF THROMBOSIS OR EMBOLISMS
    ✓ 
    Drug substance
    ✓ 
    Drug product
  
  

Related Exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

• Exclusivity expiration dates:
  • July 10, 2014 - NEW CHEMICAL ENTITY
  
  

See also...

• Effient Consumer Information (Drugs.com)
• Effient Consumer Information (Wolters Kluwer)
• Effient Consumer Information (Cerner Multum)
• Effient Advanced Consumer Information (Micromedex)
• Effient AHFS DI Monographs (ASHP)
• Prasugrel Consumer Information (Wolters Kluwer)
• Prasugrel Consumer Information (Cerner Multum)
• Prasugrel Advanced Consumer Information (Micromedex)
• Prasugrel AHFS DI Monographs (ASHP)

Cosy

Cosy may be available in the countries listed below.

Ingredient matches for Cosy

Domperidone

Domperidone is reported as an ingredient of Cosy in the following countries:

• Bangladesh

International Drug Name Search

Glaunorm

Glaunorm may be available in the countries listed below.

Ingredient matches for Glaunorm

Aceclidine

Aceclidine hydrochloride (a derivative of Aceclidine) is reported as an ingredient of Glaunorm in the following countries:

• Greece


• Italy

International Drug Name Search

Defendog

Defendog may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Defendog

Permethrin

Permethrin is reported as an ingredient of Defendog in the following countries:

• Belgium


• France


• Italy


• Netherlands


• Portugal


• Switzerland

International Drug Name Search

ThyroSafe

Pronunciation: poe-TASS-ee-uhm EYE-oh-dide
Generic Name: Potassium Iodide
Brand Name: Examples include Iosat and ThyroSafe

Take ThyroSafe only as recommended. Do NOT take more than the recommended dose or take ThyroSafe more often than recommended. Taking too much of ThyroSafe may increase the risk of side effects. Do NOT take ThyroSafe if you are allergic to iodine.

ThyroSafe is used for:

Protecting the thyroid gland from the toxic effects of radioactive iodine. ThyroSafe should only be used in a nuclear radiation emergency.

ThyroSafe is a thyroid blocking agent. It works by blocking or reducing the chances that radioactive iodine, which may be breathed in or swallowed during a nuclear emergency, will enter the thyroid gland and cause damage.

Do NOT use ThyroSafe if:

• you are allergic to any ingredient in ThyroSafe or to iodine


• you have high blood levels of urea or other nitrogenous substances (azotemia), certain skin or blood vessel problems (dermatitis herpetiformis, hypocomplementemic vasculitis), decreased urination (oliguria), or high blood potassium levels


• you have abnormal growths on the thyroid gland (nodular thyroid disease) and you have heart disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using ThyroSafe:

Some medical conditions may interact with ThyroSafe. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney problems


• if you have a history of thyroid problems

Some MEDICINES MAY INTERACT with ThyroSafe. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Lithium because the risk of hypothyroidism (low thyroid levels) may be increased


• Aldosterone blockers (eg, eplerenone), angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), potassium-sparing diuretics (eg, spironolactone), or potassium supplements because the risk of serious side effects, including high blood potassium and irregular heartbeat, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if ThyroSafe may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ThyroSafe:

Use ThyroSafe as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with ThyroSafe. Talk to your pharmacist if you have questions about this information.


• Take ThyroSafe by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Do NOT remove the tablets from the foil package until you are ready to take ThyroSafe.


• Swallow ThyroSafe whole. If you cannot swallow the tablet whole, it may be crushed and mixed with liquid.


• To prepare a liquid mixture with ThyroSafe: Place 1 tablet into a small bowl and grind it into a fine powder using the back of a metal spoon against the inside of the bowl. Add 4 teaspoonfuls (20 mL) of water to the crushed powder and mix until the powder is dissolved. Take the mixture and mix it with 4 teaspoonfuls (20 mL) of low-fat white or chocolate milk, orange juice, flat soda, raspberry syrup, or infant formula. Ask your pharmacist if you have questions about how to prepare the liquid mixture.
  
  • This mixture can be stored in the refrigerator for up to 7 days. Discard any unused portion.
  
  
  • Take the exact recommended dose. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  
  


• If you are instructed to take more than 1 dose of ThyroSafe, do NOT take it sooner than 24 hours after the last dose of ThyroSafe. Do NOT take more than 1 dose per day.


• If you miss a dose of ThyroSafe, take it as soon as possible. If you are instructed to take more than 1 dose of ThyroSafe and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once.

Ask your health care provider any questions you may have about how to use ThyroSafe.

Important safety information:

• Do NOT take more than the recommended dose, or take ThyroSafe more often or longer than recommended. Taking too much of ThyroSafe may increase the risk of serious side effects.


• Do not use a salt substitute or a potassium supplement without checking with your doctor.


• Stop taking ThyroSafe and contact your health care provider if any of the following signs of iodine poisoning occur: burning of the mouth or throat, severe headache, metallic taste in the mouth, soreness of the teeth and gums, irritation of the eyes with swelling of the eyelids, or increased salivation.


• Caution is advised when using ThyroSafe in CHILDREN; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: ThyroSafe may cause harm to the fetus. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of taking ThyroSafe while you are pregnant. ThyroSafe is found in breast milk. If you are or will be breast-feeding while you take ThyroSafe, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ThyroSafe:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; mild fever; mild headache; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing, speaking, or swallowing; tightness in the chest; swelling of the feet, hands, mouth, face, lips, throat, or tongue; wheezing or shortness of breath); chest pain; confusion; fever with joint pain; irregular heartbeat; metallic taste in the mouth; mouth sores; numbness or tingling of the hands or feet; swollen glands in the mouth (salivary glands).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: ThyroSafe side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include burning of the mouth or throat; chest pain; increased salivation; irregular heartbeat; muscle weakness; severe headache; soreness of the teeth or gums; swelling.

Proper storage of ThyroSafe:

Store ThyroSafe at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do NOT open the foil package until you are ready to use ThyroSafe. Do not store in the bathroom. Keep ThyroSafe out of the reach of children and away from pets.

General information:

• If you have any questions about ThyroSafe, please talk with your doctor, pharmacist, or other health care provider.


• ThyroSafe is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about ThyroSafe. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More ThyroSafe resources

• ThyroSafe Side Effects (in more detail)
• ThyroSafe Use in Pregnancy & Breastfeeding
• ThyroSafe Drug Interactions
• ThyroSafe Support Group
• 1 Review for ThyroSafe - Add your own review/rating

Compare ThyroSafe with other medications

• Cough
• Cutaneous Sporotrichosis
• Hyperthyroidism
• Radiation Emergency

Triaminic Multi-Sympton

Generic Name: chlorpheniramine, dextromethorphan, and pseudoephedrine (klor feh NEER a meen, dex tro meh THOR fan, and soo doe eh FEH drin)

Brand Names: AccuHist PDX Drops, Atuss DS, Children's NyQuil, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Dicel DM, Dicel DM Chewables, Entre-S, Esocor P, Kidcare Cough and Cold, M-End DM, Mesehist DM, Neutrahist PDX Drops, Nyquil Child Cough and Cold, Pediatric Cough & Cold Medicine, Rescon-DM, Robitussin Pediatric Night Relief, Robitussin PM Cough & Cold, Triaminic Cold and Cough, Triaminic Multi-Sympton, Triaminic Night Time, Triaminic Softchew Cold and Cough, Triaminic-D Multi-Symptom Cold, Vicks 44M Pediatric, Vicks Pediatric Formula 44M

What is Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, dextromethorphan, and pseudoephedrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist before taking this medicine if you have heart disease, high blood pressure, kidney disease, diabetes, glaucoma, a thyroid disorder, emphysema or bronchitis, an enlarged prostate, or urination problems.

Do not use cold or cough medicine without your doctor's advice if you are pregnant or breast-feeding. Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine, dextromethorphan, and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant. Do not take this medicine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  heart disease or high blood pressure;

  
  


• 
  

  kidney disease;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  emphysema or chronic bronchitis;

  
  


• 
  

  an enlarged prostate; or

  
  


• 
  

  problems with urination.

  
  

FDA pregnancy category C. It is not known whether chlorpheniramine, dextromethorphan, and pseudoephedrine will harm an unborn baby. Do not use this medication without medical advice if you are pregnant. Chlorpheniramine, dextromethorphan, and pseudoephedrine may pass into breast milk and may harm a nursing baby. Do not use cold or cough medicine without medical advice if you are breast-feeding a baby.

Artificially sweetened liquid cough or cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet should be chewed before you swallow it.

Shake the oral suspension well just before you measure a dose. Do not take this medicine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Chlorpheniramine can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can increase certain side effects of this medication.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Chlorpheniramine, dextromethorphan, and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant.

Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  slow, shallow breathing;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  mild stomach pain, constipation;

  
  


• 
  

  blurred vision;

  
  


• 
  

  dizziness, drowsiness, mild headache;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  feeling restless or excited (especially in children);

  
  


• 
  

  problems with memory or concentration; or

  
  


• 
  

  flushing (warmth, redness, or tingly feeling).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Triaminic Multi-Sympton (chlorpheniramine, dextromethorphan, and pseudoephedrine)?

Before using this medicine, tell your doctor if you regularly use other medicines that make you sleepy (such as sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, dextromethorphan, and pseudoephedrine.

Ask a doctor or pharmacist if it is safe for you to use chlorpheniramine, dextromethorphan, and pseudoephedrine if you are also using any of the following drugs:

• 
  

  glycopyrrolate (Robinul);

  
  


• 
  

  mepenzolate (Cantil);

  
  


• 
  

  atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  
  


• 
  

  a diuretic (water pill), or blood pressure medicine;

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

  
  


• 
  

  salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others.

  
  

This list is not complete and other drugs may interact with chlorpheniramine, dextromethorphan, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Triaminic Multi-Sympton resources

• Triaminic Multi-Sympton Side Effects (in more detail)
• Triaminic Multi-Sympton Use in Pregnancy & Breastfeeding
• Triaminic Multi-Sympton Drug Interactions
• Triaminic Multi-Sympton Support Group
• 3 Reviews for Triaminic Multi-Sympton - Add your own review/rating

• AccuHist PDX Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• AccuHist PDX Drops Prescribing Information (FDA)


• Dicel DM Chewables Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Entre-S Prescribing Information (FDA)

Compare Triaminic Multi-Sympton with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, dextromethorphan, and pseudoephedrine.

See also: Triaminic Multi-Sympton side effects (in more detail)

Tessalon

benzonatate

Dosage Form: capsule
Tessalon (benzonatate, USP)

100 mg Pereles

200 mg Capsules

Rx Only

Tessalon Description

Tessalon, a non-narcotic oral antitussive agent, is 2, 5, 8, 11, 14, 17, 20, 23, 26-nonaoxaoctacosan-28-yl p-(butylamino) benzoate; with a molecular weight of 603.7.

Each Tessalon Perle contains:

Benzonatate, USP 100 mg

Each Tessalon Capsule contains:

Benzonatate, USP 200 mg

Tessalon Capsules also contain: D&C Yellow 10, gelatin, glycerin, methylparaben and propylparaben.

Tessalon - Clinical Pharmacology

Tessalon acts peripherally by anesthetizing the stretch receptors located in the respiratory passages, lungs, and pleura by dampening their activity and thereby reducing the cough reflex at its source. It begins to act within 15 to 20 minutes and its effect lasts for 3 to 8 hours. Tessalon has no inhibitory effect on the respiratory center in recommended dosage.

Indications and Usage for Tessalon

Tessalon is indicated for the symptomatic relief of cough.

Contraindications

Hypersensitivity to benzonatate or related compounds.

Warnings

Hypersensitivity

Severe hypersensitivity reactions (including bronchospasm, laryngospasm and cardiovascular collapse) have been reported which are possibly related to local anesthesia from sucking or chewing the capsule instead of swallowing it. Severe reactions have required intervention with vasopressor agents and supportive measures.

Psychiatric Effects

Isolated instances of bizarre behavior, including mental confusion and visual hallucinations, have also been reported in patients taking Tessalon in combination with other prescribed drugs.

Accidental Ingestion and Death in Children

Keep Tessalon out of reach of children. Accidental ingestion of Tessalon resulting in death has been reported in children below age 10. Signs and symptoms of overdose have been reported within 15-20 minutes and death has been reported within one hour of ingestion. If accidental ingestion occurs, seek medical attention immediately (see OVERDOSAGE).

Precautions

Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication.

Information for Patients

Swallow Tessalon Capsules and Perles whole. Do not break, chew, dissolve, cut, or crush Tessalon Capsules and Perles. Release of Tessalon from the capsule in the mouth can produce a temporary local anesthesia of the oral mucosa and choking could occur. If numbness or tingling of the tongue, mouth, throat, or face occurs, refrain from oral ingestion of food or liquids until the numbness has resolved. If the symptoms worsen or persist, seek medical attention.

Keep Tessalon out of reach of children. Accidental ingestion resulting in death has been reported in children. Signs and symptoms of overdose have been reported within 15-20 minutes and death has been reported within one hour of ingestion. Signs and symptoms may include restlessness, tremors, convulsions, coma and cardiac arrest. If accidental ingestion occurs, seek medical attention immediately.

Overdosage resulting in death may occur in adults.

Do not exceed a single dose of 200 mg and a total daily dosage of 600 mg. If you miss a dose of Tessalon, skip that dose and take the next dose at the next scheduled time. Do not take 2 doses of Tessalon at one time.

Usage in Pregnancy

PREGNANCY CATEGORY C

Animal reproduction studies have not been conducted with Tessalon. It is also not known whether Tessalon can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Tessalon should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk caution should be exercised when Tessalon is administered to a nursing woman.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenicity, mutagenicity, and reproduction studies have not been conducted with Tessalon.

Pediatric Use

Safety and effectiveness in children below the age of 10 have not been established. Accidental ingestion resulting in death has been reported in children below age 10. Keep out of reach of children.

Adverse Reactions

Potential Adverse Reactions to Tessalon may include:

Hypersensitivity reactions including bronchospasm, laryngospasm, cardiovascular collapse possibly related to local anesthesia from chewing or sucking the capsule.

CNS

sedation; headache; dizziness; mental confusion; visual hallucinations.

GI

constipation; nausea; GI upset.

Dermatologic

pruritus; skin eruptions.

Other

nasal congestion; sensation of burning in the eyes; vague “chilly” sensation; numbness of the chest; hypersensitivity.

Deliberate or accidental overdose has resulted in death, particularly in children.

Overdosage

Intentional and unintentional overdose may result in death, particularly in children.

The drug is chemically related to tetracaine and other topical anesthetics and shares various aspects of their pharmacology and toxicology. Drugs of this type are generally well absorbed after ingestion.

Signs and Symptoms

The signs and symptoms of overdose of benzonatate have been reported within 15-20 minutes. If capsules are chewed or dissolved in the mouth, oropharyngeal anesthesia will develop rapidly, which may cause choking and airway compromise.

CNS stimulation may cause restlessness and tremors which may proceed to clonic convulsions followed by profound CNS depression. Convulsions, coma, cerebral edema and cardiac arrest leading to death have been reported within 1 hour of ingestion.

Treatment

In case of overdose, seek medical attention immediately. Evacuate gastric contents and administer copious amounts of activated charcoal slurry. Even in the conscious patient, cough and gag reflexes may be so depressed as to necessitate special attention to protection against aspiration of gastric contents and orally administered materials. Convulsions should be treated with a short-acting barbiturate given intravenously and carefully titrated for the smallest effective dosage. Intensive support of respiration and cardiovascular-renal function is an essential feature of the treatment of severe intoxication from overdosage.

Do not use CNS stimulants.

Tessalon Dosage and Administration

Adults and Children over 10 years of age: Usual dose is one 100 mg or 200 mg capsule three times a day as needed for cough. If necessary to control cough, up to 600 mg daily in three divided doses may be given. Tessalon should be swallowed whole. Tessalon Capsules and Perles are not to be broken, chewed, dissolved, cut or crushed.

How is Tessalon Supplied

Perles, 100 mg (yellow);

bottles of 100

NDC 0069-0122-01

Imprint: T.

Perles, 100 mg (yellow);

bottles of 500

NDC 0069-0122-02

Imprint: T

Capsules, 200 mg (yellow);

bottles of 100

NDC 0069-0124-01

Imprint: 0698.

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].

Rev. 12/15

Mfd by

Catalent Pharma Solutions

St. Petersburg, Florida 33716

Pfizer Inc.

Madison, New Jersey 07940

©2010 Pfizer Inc.

PRODUCT PACKAGING

Tessalon 100 mg/200 mg (benzonatate, USP) perles/capsules

See package insert for dosage information

Dispensing package for professional use only.

Dispense in a tight, light-resistant container as defined in the USP.

KEEP TIGHTLY CLOSED

Tessalon  benzonatate  capsule

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0069-0122 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength benzonatate (benzonatate) benzonatate 100 mg

Inactive Ingredients Ingredient Name Strength D&C Yellow No. 10   Gelatin   Glycerin   Methylparaben   Propylparaben

Product Characteristics Color YELLOW Score no score Shape ROUND Size 7mm Flavor Imprint Code T Contains

Packaging # NDC Package Description Multilevel Packaging 1 0069-0122-01 100 CAPSULE In 1 BOTTLE None 2 0069-0122-02 500 CAPSULE In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA011210	02/10/1958

Tessalon  benzonatate  capsule

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0069-0124 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength benzonatate (benzonatate) benzonatate 200 mg

Inactive Ingredients Ingredient Name Strength D&C Yellow No. 10   Gelatin   Glycerin   Methylparaben   Propylparaben

Product Characteristics Color YELLOW Score no score Shape OVAL Size 12mm Flavor Imprint Code 0698 Contains

Packaging # NDC Package Description Multilevel Packaging 1 0069-0124-01 100 CAPSULE In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA011210	06/25/1999

Labeler - Pfizer Laboratories (134489525)

Establishment
Name	Address	ID/FEI	Operations
Catalent Pharma Solutions, LLC		051762268	MANUFACTURE

Revised: 02/2011Pfizer Laboratories

More Tessalon resources

• Tessalon Side Effects (in more detail)
• Tessalon Dosage
• Tessalon Use in Pregnancy & Breastfeeding
• Drug Images
• Tessalon Drug Interactions
• Tessalon Support Group
• 6 Reviews for Tessalon - Add your own review/rating

• Tessalon Concise Consumer Information (Cerner Multum)


• Tessalon Monograph (AHFS DI)


• Benzonatate Professional Patient Advice (Wolters Kluwer)


• benzonatate Advanced Consumer (Micromedex) - Includes Dosage Information


• Benzonatate MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Tessalon with other medications

• Cough

Citrate of Magnesia Solution

Pronunciation: mag-NEE-zee-um SEYE-trate
Generic Name: Magnesium Citrate
Brand Name: Examples include Citrate of Magnesia and LiquiPrep

Citrate of Magnesia Solution is used for:

Clearing the bowels before tests or for treating constipation.

Citrate of Magnesia Solution is a laxative. It works by attracting and retaining water in the intestine, which allows the bowel to evacuate.

Do NOT use Citrate of Magnesia Solution if:

• you are allergic to any ingredient in Citrate of Magnesia Solution


• you are taking aluminum salt (eg, aluminum hydroxide) or quinolones (eg, ciprofloxacin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Citrate of Magnesia Solution:

Some medical conditions may interact with Citrate of Magnesia Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of bowel obstruction or kidney conditions, appendicitis, heart failure, or rectal bleeding

Some MEDICINES MAY INTERACT with Citrate of Magnesia Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aluminum salts (eg, aluminum hydroxide) or anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Citrate of Magnesia Solution


• Bisphosphonates (eg, risedronate), digoxin, penicillamine, quinolone antibiotics (eg, ciprofloxacin), or tetracyclines (eg, doxycycline) because their effectiveness may be decreased by Citrate of Magnesia Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Citrate of Magnesia Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Citrate of Magnesia Solution:

Use Citrate of Magnesia Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Citrate of Magnesia Solution on an empty stomach. Take Citrate of Magnesia Solution with a full glass of water (8 oz/240 mL).


• If you also take a bisphosphonate (eg, alendronic acid), digoxin, or a tetracycline (eg, doxycycline), do not take them within 2 to 4 hours of taking Citrate of Magnesia Solution. Check with your doctor if you have questions.


• If you miss a dose of Citrate of Magnesia Solution, take it as soon as you remember. Continue to take it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Citrate of Magnesia Solution.

Important safety information:

• Do not use Citrate of Magnesia Solution if you experience abdominal pain, nausea, vomiting, or rectal bleeding except under the direction of your doctor.


• If you notice a sudden change in bowel habits that lasts for 2 weeks or more, check with your doctor and do not use any more of Citrate of Magnesia Solution.


• Do NOT take more than the recommended dose or use for longer than 1 week without checking with your doctor.


• Citrate of Magnesia Solution should not be used in CHILDREN younger than 2 years old; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Citrate of Magnesia Solution while you are pregnant. It is not known if Citrate of Magnesia Solution is found in breast milk. If you are or will be breast-feeding while you use Citrate of Magnesia Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Citrate of Magnesia Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; stomach discomfort.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the stool; cramps; dizziness; fainting; irregular heartbeat; severe diarrhea; sweating; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Citrate of Magnesia side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Citrate of Magnesia Solution:

Store Citrate of Magnesia Solution at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Citrate of Magnesia Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Citrate of Magnesia Solution, please talk with your doctor, pharmacist, or other health care provider.


• Citrate of Magnesia Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Citrate of Magnesia Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Citrate of Magnesia resources

• Citrate of Magnesia Side Effects (in more detail)
• Citrate of Magnesia Use in Pregnancy & Breastfeeding
• Citrate of Magnesia Drug Interactions
• Citrate of Magnesia Support Group
• 1 Review for Citrate of Magnesia - Add your own review/rating

Compare Citrate of Magnesia with other medications

• Constipation

Guayfenesina Naturgen

Guayfenesina Naturgen may be available in the countries listed below.

Ingredient matches for Guayfenesina Naturgen

Guaifenesin

Guaifenesin is reported as an ingredient of Guayfenesina Naturgen in the following countries:

• Peru

International Drug Name Search

mazindol

Generic Name: mazindol (MA zin doll)

Brand Names: Mazanor, Sanorex

What is mazindol?

Mazindol is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or an "anorexigenic" drug. Mazindol stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Mazindol is used as a short-term supplement to diet and exercise in the treatment of obesity.

Mazindol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about mazindol?

Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities. Mazindol is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Who should not take mazindol?

You cannot take mazindol if you

• 
  

  have heart disease or high blood pressure;

  
  


• 
  

  have arteriosclerosis (hardening of the arteries);

  
  


• 
  

  have glaucoma;

  
  


• 
  

  have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or

  
  


• 
  

  have a history of drug or alcohol abuse.

  
  

Before taking this medication, tell your doctor if you have

• 
  

  problems with your thyroid;

  
  


• 
  

  an anxiety disorder;

  
  


• 
  

  epilepsy or another seizure disorder; or

  
  


• 
  

  diabetes.

  
  

You may not be able to take mazindol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether mazindol will harm an unborn baby. Do not take mazindol without first talking to your doctor if you are pregnant. It is also not known whether mazindol passes into breast milk. Do not take mazindol without first talking to your doctor if you are breast-feeding a baby.

How should I take mazindol?

Take mazindol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Mazindol is usually taken one to three times a day before meals. Mazindol can be taken with food if it upsets your stomach. Follow your doctor's instructions. Never take more of this medication than is prescribed for you. Too much mazindol could be very dangerous to your health. Store mazindol at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose or if it is already evening, skip the missed dose and take only your next regularly scheduled dose. A dose taken too late in the day will cause insomnia. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a mazindol overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

What should I avoid while taking mazindol?

Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

Mazindol side effects

If you experience any of the following serious side effects, stop taking mazindol and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or

  
  


• 
  

  hallucinations, abnormal behavior, or confusion.

  
  

Other, less serious side effects may be more likely to occur. Continue to take mazindol and talk to your doctor if you experience

• 
  

  restlessness or tremor,

  
  


• 
  

  nervousness or anxiety,

  
  


• 
  

  headache or dizziness,

  
  


• 
  

  insomnia,

  
  


• 
  

  dry mouth or an unpleasant taste in your mouth,

  
  


• 
  

  diarrhea or constipation, or

  
  


• 
  

  impotence or changes in your sex drive.

  
  

Mazindol is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect mazindol?

You cannot take mazindol if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Changes in insulin and other diabetes drug therapies may be necessary during treatment with mazindol.

Mazindol may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.

Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of mazindol.

Drugs other than those listed here may also interact with mazindol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More mazindol resources

• Mazindol Drug Interactions
• Mazindol Support Group
• 0 Reviews for Mazindol - Add your own review/rating

Compare mazindol with other medications

• Obesity
• Weight Loss

Where can I get more information?

• Your pharmacist has more information about mazindol written for health professionals that you may read.

What does my medication look like?

Mazindol is available with a prescription under the brand names Mazanor and Sanorex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• 
  

  Mazanor 1 mg--white, round, scored tablets

  
  


• 
  

  Sanorex 1 mg--white, round tablets

  
  


• 
  

  Sanorex 2 mg--white, round, scored tablets

  
  

Sevorane

Sevorane may be available in the countries listed below.

Ingredient matches for Sevorane

Sevoflurane

Sevoflurane is reported as an ingredient of Sevorane in the following countries:

• Argentina


• Australia


• Austria


• Belgium


• Bosnia & Herzegowina


• Brazil


• Bulgaria


• Canada


• Chile


• China


• Costa Rica


• Croatia (Hrvatska)


• Czech Republic


• Denmark


• Estonia


• Finland


• France


• Germany


• Greece


• Guatemala


• Honduras


• Hong Kong


• Hungary


• Iceland


• Indonesia


• Israel


• Italy


• Latvia


• Lithuania


• Luxembourg


• Mexico


• New Zealand


• Nicaragua


• Norway


• Panama


• Peru


• Philippines


• Poland


• Romania


• Serbia


• Singapore


• Slovakia


• Slovenia


• Spain


• Sweden


• Switzerland


• Thailand


• Tunisia


• Turkey


• Venezuela

International Drug Name Search

Amiodarone Arrow

Amiodarone Arrow may be available in the countries listed below.

Ingredient matches for Amiodarone Arrow

Amiodarone

Amiodarone hydrochloride (a derivative of Amiodarone) is reported as an ingredient of Amiodarone Arrow in the following countries:

• France

International Drug Name Search

Tazarotene Cream

Pronunciation: taz-AR-oh-teen
Generic Name: Tazarotene
Brand Name: Tazorac

Tazarotene Cream is used for:

Treating psoriasis. It may also be used for other conditions as determined by your doctor.

Tazarotene Cream is a retinoid. The specific way Tazarotene Cream works is not completely understood. It may decrease skin inflammation and skin changes associated with psoriasis.

Do NOT use Tazarotene Cream if:

• you are allergic to any ingredient in Tazarotene Cream


• you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tazarotene Cream:

Some medical conditions may interact with Tazarotene Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are of childbearing age


• if you have eczema, a sunburn, or high blood lipid levels, or if you are unusually sensitive to sunlight

Some MEDICINES MAY INTERACT with Tazarotene Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), thiazide diuretics (eg, hydrochlorothiazide), or vitamin A because the risk of sunburn may be increased by Tazarotene Cream

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tazarotene Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tazarotene Cream:

Use Tazarotene Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Tazarotene Cream. Talk to your pharmacist if you have questions about this information.


• Tazarotene Cream is for external use only.


• Apply Tazarotene Cream using a thin film to cover the lesion only.


• If a bath or shower is taken before applying Tazarotene Cream, make sure that the skin is dry before applying Tazarotene Cream.


• Do not allow Tazarotene Cream to come into contact with unaffected skin.


• Wash your hands immediately after using Tazarotene Cream, unless you have psoriasis on your hands.


• If you miss a dose of Tazarotene Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tazarotene Cream.

Important safety information:

• If your symptoms do not get better within 2 weeks or if they get worse, check with your doctor.


• Avoid getting Tazarotene Cream in your eyes, nose, mouth, vagina, or on healthy skin. If you get Tazarotene Cream in your eyes, rinse thoroughly with water.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Tazarotene Cream.


• Talk with your doctor before you use any other medicines, cleansers, sunscreen or makeup on your skin.


• Do not use Tazarotene Cream on skin with eczema, or for any condition other than that for which it was prescribed.


• If you have a sunburn, do not use Tazarotene Cream on the sunburned skin until it has fully healed.


• Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tazarotene Cream.


• If you are using a cream or lotion to soften or moisten your skin, do not apply Tazarotene Cream until the first cream or lotion has been absorbed into your skin (at least 1 hour).


• Tazarotene Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Do not cover the treated area with dressings or bandages.


• Tazarotene Cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tazarotene Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tazarotene Cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• Women of childbearing potential should use effective birth control methods (eg, condoms, birth control pills, diaphragms) while using Tazarotene Cream. You should have a negative pregnancy test 2 weeks before starting Tazarotene Cream. Contact your health care provider at once if you become pregnant while using Tazarotene Cream.


• PREGNANCY and BREAST-FEEDING: Do not use Tazarotene Cream if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Tazarotene Cream is found in breast milk. Do not breast-feed while taking Tazarotene Cream.

Possible side effects of Tazarotene Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning; dry skin; irritation; itching; peeling; redness; scaling; skin inflammation; skin pain; stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or prolonged itching, burning, redness, or peeling; sunburn; swelling of the skin, hands, or feet; worsening of psoriasis.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tazarotene side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe redness, peeling, or discomfort. Tazarotene Cream may be harmful if swallowed.

Proper storage of Tazarotene Cream:

Store Tazarotene Cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 23 and 86 degrees F (-5 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tazarotene Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Tazarotene Cream, please talk with your doctor, pharmacist, or other health care provider.


• Tazarotene Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tazarotene Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tazarotene resources

• Tazarotene Side Effects (in more detail)
• Tazarotene Use in Pregnancy & Breastfeeding
• Tazarotene Drug Interactions
• Tazarotene Support Group
• 2 Reviews for Tazarotene - Add your own review/rating

Compare Tazarotene with other medications

• Acne
• Facial Wrinkles
• Psoriasis

Tocinox

Tocinox may be available in the countries listed below.

Ingredient matches for Tocinox

Oxytocin

Oxytocin is reported as an ingredient of Tocinox in the following countries:

• Myanmar

International Drug Name Search

tesamorelin

Generic Name: tesamorelin (TES a moe REL in)

Brand Names: Egrifta

What is tesamorelin?

Tesamorelin is made with growth hormone-releasing factor (GRF).

Tesamorelin is used to reduce excess fat around the stomach that is caused by taking certain HIV medications. This condition is also called lipodystrophy (LYE-poe-DIS-troe-fee).

Tesamorelin is not a weight-loss medication and should not be used to treat obesity.

What is the most important information I should know about tesamorelin?

Tesamorelin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. You should not use tesamorelin if you are allergic to it, or if you have a history of tumor or surgery of your pituitary gland, a history of head injury or radiation treatment,

Before using tesamorelin, tell your doctor if you have heart disease, high blood pressure, kidney disease, diabetes, epilepsy, asthma, migraines, an adrenal gland disorder, or if you have ever had cancer, any type of tumor, or open heart surgery.

Also tell your doctor about any major illness or recent trauma or medical emergency.

What should I discuss with my healthcare provider before using tesamorelin?

You should not use tesamorelin if you are allergic to it, or if you have:

• 
  

  cancer;

  
  


• 
  

  a pituitary gland disorder;

  
  


• 
  

  a history of pituitary gland tumor or surgery;

  
  


• 
  

  a history of head injury or radiation treatment; or

  
  


• 
  

  if you are pregnant.

  
  

To make sure you can safely take tesamorelin, tell your doctor if you have any of these other conditions:

• 
  

  a history of cancer or any tumor (either benign or malignant);

  
  


• 
  

  heart disease, high blood pressure;

  
  


• 
  

  kidney disease;

  
  


• 
  

  diabetes, eye problems caused by diabetes;

  
  


• 
  

  epilepsy

  
  


• 
  

  asthma;

  
  


• 
  

  migraine headaches;

  
  


• 
  

  adrenal gland disorder;

  
  


• 
  

  if you have ever had open heart surgery; or

  
  


• 
  

  if you have any major illness, or a recent trauma or medical emergency.

  
  

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use tesamorelin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Do not give this medicine to a child without medical advice.

How tesamorelin given?

Tesamorelin is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with injection instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Tesamorelin is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription. After mixing tesamorelin with a diluent, you must use it right away. Do not store the mixture for later use.

Tesamorelin is usually given once per day. Follow your doctor's dosing instructions very carefully.

Use a different place on your stomach each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Never share a tesamorelin syringe with another person, even if you change the needle. Sharing syringes or needles can allow HIV or other diseases to pass from one person to another.

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.

Store vials of tesamorelin powder in the refrigerator, do not freeze. Store the diluent at room temperature away from moisture, heat, and light.

Throw away any unused vials after the expiration date on the label has passed.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of tesamorelin.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tesamorelin?

Do not inject this medicine into scar tissue or on skin that is bruised. Do not inject directly into your navel (belly-button).

Tesamorelin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using tesamorelin and call your doctor at once if you have a serious side effect such as:

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  swelling in your hands, ankles, or feet;

  
  


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  pain or stiffness in your muscles or joints;

  
  


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  pain in your arms or legs;

  
  


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  wrist pain or numbness;

  
  


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  numbness or tingling in your hands or fingers;

  
  


• 
  

  pounding heartbeats or fluttering in your chest;

  
  


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  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  
  

Less serious side effects may include:

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  depressed mood, sleep problems (insomnia);

  
  


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  night sweats;

  
  


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  mild rash or itching;

  
  


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  muscle spasm;

  
  


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  nausea, vomiting, upset stomach;

  
  


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  pain, redness, itching, swelling, bruising, bleeding, or other irritation where the injection was given;

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tesamorelin Dosing Information

Usual Adult Dose for Lipodystrophy:

For the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy:
2 mg injected subcutaneously once a day.

What other drugs will affect tesamorelin?

Tell your doctor about all other medicines you use, especially:

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  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


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  testosterone or hormone replacement therapy;

  
  


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  seizure medication;

  
  


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  steroids (prednisone and others);

  
  

This list is not complete and there are many other drugs that can interact with tesamorelin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More tesamorelin resources

• Tesamorelin Side Effects (in more detail)
• Tesamorelin Use in Pregnancy & Breastfeeding
• Tesamorelin Drug Interactions
• Tesamorelin Support Group
• 2 Reviews for Tesamorelin - Add your own review/rating

• tesamorelin Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information


• Tesamorelin Professional Patient Advice (Wolters Kluwer)


• Tesamorelin MedFacts Consumer Leaflet (Wolters Kluwer)


• Egrifta Prescribing Information (FDA)


• Egrifta Consumer Overview

Compare tesamorelin with other medications

• Lipodystrophy

Where can I get more information?

• Your pharmacist can provide more information about tesamorelin.

See also: tesamorelin side effects (in more detail)

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