mazindol

Generic Name: mazindol (MA zin doll)

Brand Names: Mazanor, Sanorex

What is mazindol?

Mazindol is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or an "anorexigenic" drug. Mazindol stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Mazindol is used as a short-term supplement to diet and exercise in the treatment of obesity.

Mazindol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about mazindol?

Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities. Mazindol is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Who should not take mazindol?

You cannot take mazindol if you

• 
  

  have heart disease or high blood pressure;

  
  


• 
  

  have arteriosclerosis (hardening of the arteries);

  
  


• 
  

  have glaucoma;

  
  


• 
  

  have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or

  
  


• 
  

  have a history of drug or alcohol abuse.

  
  

Before taking this medication, tell your doctor if you have

• 
  

  problems with your thyroid;

  
  


• 
  

  an anxiety disorder;

  
  


• 
  

  epilepsy or another seizure disorder; or

  
  


• 
  

  diabetes.

  
  

You may not be able to take mazindol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether mazindol will harm an unborn baby. Do not take mazindol without first talking to your doctor if you are pregnant. It is also not known whether mazindol passes into breast milk. Do not take mazindol without first talking to your doctor if you are breast-feeding a baby.

How should I take mazindol?

Take mazindol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Mazindol is usually taken one to three times a day before meals. Mazindol can be taken with food if it upsets your stomach. Follow your doctor's instructions. Never take more of this medication than is prescribed for you. Too much mazindol could be very dangerous to your health. Store mazindol at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose or if it is already evening, skip the missed dose and take only your next regularly scheduled dose. A dose taken too late in the day will cause insomnia. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a mazindol overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

What should I avoid while taking mazindol?

Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

Mazindol side effects

If you experience any of the following serious side effects, stop taking mazindol and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or

  
  


• 
  

  hallucinations, abnormal behavior, or confusion.

  
  

Other, less serious side effects may be more likely to occur. Continue to take mazindol and talk to your doctor if you experience

• 
  

  restlessness or tremor,

  
  


• 
  

  nervousness or anxiety,

  
  


• 
  

  headache or dizziness,

  
  


• 
  

  insomnia,

  
  


• 
  

  dry mouth or an unpleasant taste in your mouth,

  
  


• 
  

  diarrhea or constipation, or

  
  


• 
  

  impotence or changes in your sex drive.

  
  

Mazindol is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect mazindol?

You cannot take mazindol if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Changes in insulin and other diabetes drug therapies may be necessary during treatment with mazindol.

Mazindol may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.

Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of mazindol.

Drugs other than those listed here may also interact with mazindol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More mazindol resources

• Mazindol Drug Interactions
• Mazindol Support Group
• 0 Reviews for Mazindol - Add your own review/rating

Compare mazindol with other medications

• Obesity
• Weight Loss

Where can I get more information?

• Your pharmacist has more information about mazindol written for health professionals that you may read.

What does my medication look like?

Mazindol is available with a prescription under the brand names Mazanor and Sanorex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• 
  

  Mazanor 1 mg--white, round, scored tablets

  
  


• 
  

  Sanorex 1 mg--white, round tablets

  
  


• 
  

  Sanorex 2 mg--white, round, scored tablets

  
  

Sevorane

Sevorane may be available in the countries listed below.

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Sevoflurane

Sevoflurane is reported as an ingredient of Sevorane in the following countries:

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International Drug Name Search

Amiodarone Arrow

Amiodarone Arrow may be available in the countries listed below.

Ingredient matches for Amiodarone Arrow

Amiodarone

Amiodarone hydrochloride (a derivative of Amiodarone) is reported as an ingredient of Amiodarone Arrow in the following countries:

• France

International Drug Name Search

Tazarotene Cream

Pronunciation: taz-AR-oh-teen
Generic Name: Tazarotene
Brand Name: Tazorac

Tazarotene Cream is used for:

Treating psoriasis. It may also be used for other conditions as determined by your doctor.

Tazarotene Cream is a retinoid. The specific way Tazarotene Cream works is not completely understood. It may decrease skin inflammation and skin changes associated with psoriasis.

Do NOT use Tazarotene Cream if:

• you are allergic to any ingredient in Tazarotene Cream


• you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tazarotene Cream:

Some medical conditions may interact with Tazarotene Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are of childbearing age


• if you have eczema, a sunburn, or high blood lipid levels, or if you are unusually sensitive to sunlight

Some MEDICINES MAY INTERACT with Tazarotene Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), thiazide diuretics (eg, hydrochlorothiazide), or vitamin A because the risk of sunburn may be increased by Tazarotene Cream

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tazarotene Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tazarotene Cream:

Use Tazarotene Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Tazarotene Cream. Talk to your pharmacist if you have questions about this information.


• Tazarotene Cream is for external use only.


• Apply Tazarotene Cream using a thin film to cover the lesion only.


• If a bath or shower is taken before applying Tazarotene Cream, make sure that the skin is dry before applying Tazarotene Cream.


• Do not allow Tazarotene Cream to come into contact with unaffected skin.


• Wash your hands immediately after using Tazarotene Cream, unless you have psoriasis on your hands.


• If you miss a dose of Tazarotene Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tazarotene Cream.

Important safety information:

• If your symptoms do not get better within 2 weeks or if they get worse, check with your doctor.


• Avoid getting Tazarotene Cream in your eyes, nose, mouth, vagina, or on healthy skin. If you get Tazarotene Cream in your eyes, rinse thoroughly with water.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Tazarotene Cream.


• Talk with your doctor before you use any other medicines, cleansers, sunscreen or makeup on your skin.


• Do not use Tazarotene Cream on skin with eczema, or for any condition other than that for which it was prescribed.


• If you have a sunburn, do not use Tazarotene Cream on the sunburned skin until it has fully healed.


• Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tazarotene Cream.


• If you are using a cream or lotion to soften or moisten your skin, do not apply Tazarotene Cream until the first cream or lotion has been absorbed into your skin (at least 1 hour).


• Tazarotene Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Do not cover the treated area with dressings or bandages.


• Tazarotene Cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tazarotene Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tazarotene Cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• Women of childbearing potential should use effective birth control methods (eg, condoms, birth control pills, diaphragms) while using Tazarotene Cream. You should have a negative pregnancy test 2 weeks before starting Tazarotene Cream. Contact your health care provider at once if you become pregnant while using Tazarotene Cream.


• PREGNANCY and BREAST-FEEDING: Do not use Tazarotene Cream if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Tazarotene Cream is found in breast milk. Do not breast-feed while taking Tazarotene Cream.

Possible side effects of Tazarotene Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning; dry skin; irritation; itching; peeling; redness; scaling; skin inflammation; skin pain; stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or prolonged itching, burning, redness, or peeling; sunburn; swelling of the skin, hands, or feet; worsening of psoriasis.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tazarotene side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe redness, peeling, or discomfort. Tazarotene Cream may be harmful if swallowed.

Proper storage of Tazarotene Cream:

Store Tazarotene Cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 23 and 86 degrees F (-5 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tazarotene Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Tazarotene Cream, please talk with your doctor, pharmacist, or other health care provider.


• Tazarotene Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tazarotene Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tazarotene resources

• Tazarotene Side Effects (in more detail)
• Tazarotene Use in Pregnancy & Breastfeeding
• Tazarotene Drug Interactions
• Tazarotene Support Group
• 2 Reviews for Tazarotene - Add your own review/rating

Compare Tazarotene with other medications

• Acne
• Facial Wrinkles
• Psoriasis

Tocinox

Tocinox may be available in the countries listed below.

Ingredient matches for Tocinox

Oxytocin

Oxytocin is reported as an ingredient of Tocinox in the following countries:

• Myanmar

International Drug Name Search

tesamorelin

Generic Name: tesamorelin (TES a moe REL in)

Brand Names: Egrifta

What is tesamorelin?

Tesamorelin is made with growth hormone-releasing factor (GRF).

Tesamorelin is used to reduce excess fat around the stomach that is caused by taking certain HIV medications. This condition is also called lipodystrophy (LYE-poe-DIS-troe-fee).

Tesamorelin is not a weight-loss medication and should not be used to treat obesity.

What is the most important information I should know about tesamorelin?

Tesamorelin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. You should not use tesamorelin if you are allergic to it, or if you have a history of tumor or surgery of your pituitary gland, a history of head injury or radiation treatment,

Before using tesamorelin, tell your doctor if you have heart disease, high blood pressure, kidney disease, diabetes, epilepsy, asthma, migraines, an adrenal gland disorder, or if you have ever had cancer, any type of tumor, or open heart surgery.

Also tell your doctor about any major illness or recent trauma or medical emergency.

What should I discuss with my healthcare provider before using tesamorelin?

You should not use tesamorelin if you are allergic to it, or if you have:

• 
  

  cancer;

  
  


• 
  

  a pituitary gland disorder;

  
  


• 
  

  a history of pituitary gland tumor or surgery;

  
  


• 
  

  a history of head injury or radiation treatment; or

  
  


• 
  

  if you are pregnant.

  
  

To make sure you can safely take tesamorelin, tell your doctor if you have any of these other conditions:

• 
  

  a history of cancer or any tumor (either benign or malignant);

  
  


• 
  

  heart disease, high blood pressure;

  
  


• 
  

  kidney disease;

  
  


• 
  

  diabetes, eye problems caused by diabetes;

  
  


• 
  

  epilepsy

  
  


• 
  

  asthma;

  
  


• 
  

  migraine headaches;

  
  


• 
  

  adrenal gland disorder;

  
  


• 
  

  if you have ever had open heart surgery; or

  
  


• 
  

  if you have any major illness, or a recent trauma or medical emergency.

  
  

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use tesamorelin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Do not give this medicine to a child without medical advice.

How tesamorelin given?

Tesamorelin is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with injection instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Tesamorelin is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription. After mixing tesamorelin with a diluent, you must use it right away. Do not store the mixture for later use.

Tesamorelin is usually given once per day. Follow your doctor's dosing instructions very carefully.

Use a different place on your stomach each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Never share a tesamorelin syringe with another person, even if you change the needle. Sharing syringes or needles can allow HIV or other diseases to pass from one person to another.

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.

Store vials of tesamorelin powder in the refrigerator, do not freeze. Store the diluent at room temperature away from moisture, heat, and light.

Throw away any unused vials after the expiration date on the label has passed.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of tesamorelin.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tesamorelin?

Do not inject this medicine into scar tissue or on skin that is bruised. Do not inject directly into your navel (belly-button).

Tesamorelin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using tesamorelin and call your doctor at once if you have a serious side effect such as:

• 
  

  swelling in your hands, ankles, or feet;

  
  


• 
  

  pain or stiffness in your muscles or joints;

  
  


• 
  

  pain in your arms or legs;

  
  


• 
  

  wrist pain or numbness;

  
  


• 
  

  numbness or tingling in your hands or fingers;

  
  


• 
  

  pounding heartbeats or fluttering in your chest;

  
  


• 
  

  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  
  

Less serious side effects may include:

• 
  

  depressed mood, sleep problems (insomnia);

  
  


• 
  

  night sweats;

  
  


• 
  

  mild rash or itching;

  
  


• 
  

  muscle spasm;

  
  


• 
  

  nausea, vomiting, upset stomach;

  
  


• 
  

  pain, redness, itching, swelling, bruising, bleeding, or other irritation where the injection was given;

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tesamorelin Dosing Information

Usual Adult Dose for Lipodystrophy:

For the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy:
2 mg injected subcutaneously once a day.

What other drugs will affect tesamorelin?

Tell your doctor about all other medicines you use, especially:

• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  testosterone or hormone replacement therapy;

  
  


• 
  

  seizure medication;

  
  


• 
  

  steroids (prednisone and others);

  
  

This list is not complete and there are many other drugs that can interact with tesamorelin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More tesamorelin resources

• Tesamorelin Side Effects (in more detail)
• Tesamorelin Use in Pregnancy & Breastfeeding
• Tesamorelin Drug Interactions
• Tesamorelin Support Group
• 2 Reviews for Tesamorelin - Add your own review/rating

• tesamorelin Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information


• Tesamorelin Professional Patient Advice (Wolters Kluwer)


• Tesamorelin MedFacts Consumer Leaflet (Wolters Kluwer)


• Egrifta Prescribing Information (FDA)


• Egrifta Consumer Overview

Compare tesamorelin with other medications

• Lipodystrophy

Where can I get more information?

• Your pharmacist can provide more information about tesamorelin.

See also: tesamorelin side effects (in more detail)

Central Nervous System Disorders Medications

Topics under Central Nervous System Disorders

• Adhesive Arachnoiditis (0 drugs)

• Altered Consciousness (0 drugs)

• Amyotrophic Lateral Sclerosis (1 drug)

• Autonomic Neuropathy (0 drugs in 2 topics)

• Benign Essential Tremor (9 drugs)

• Brain Anomalies incl Congenital (2 drugs in 2 topics)

• Cauda Equina Syndrome w/ Neurogenic Bladder (0 drugs)

• Cerebral Edema (13 drugs)

• Cerebral Spasticity (6 drugs in 2 topics)

• Cerebral Vascular Disorder (163 drugs in 10 topics)

• CNS Infection (1 drug in 2 topics)

• Dementia (29 drugs in 5 topics)

• Epilepsy (113 drugs in 5 topics)

• Guillain-Barre Syndrome (6 drugs in 2 topics)

• Head Injury (1 drug in 4 topics)

• Leukodystrophy (0 drugs)

• Meningitis (162 drugs in 10 topics)

• Multiple Sclerosis (57 drugs in 4 topics)

• Parkinson's Disease (44 drugs in 3 topics)

• Spinal Cord Trauma (0 drugs)

Learn more about Central Nervous System Disorders

Micromedex Care Notes:

• Alzheimer's Disease
• Hepatic Encephalopathy
• Hydrocephalus
• Hydrocephalus In Children
• Hypereosinophilic Syndrome
• Jaundice In Newborns

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